We are looking for graduate students (PhD) interested in basic endocrine research, hormonal control of reproduction and development. There are several exciting projects currently available. There is great opportunity to learn new techniques as well, including cDNA microarray analysis, bioinformatics, proteomics. Both fish and frog models are used. There are excellent opportunities to collaborate with groups within the Dept of Biology, Canada and Internationally.
THE PROJECTS AVAILABLE ARE DESCRIBED BRIEFLY BELOW. IF YOU HAVE YOUR OWN IDEAS OR PROJECTS IN MIND, PERHAPS YOU CAN PROPOSE THOSE.
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The candidate will be examining the role of sex hormones in early development using the model frog species Silurana tropicalis. Sex steroids can affect both sexual development and metamorphosis , and so do thyroid hormones. We want to understand this cross-talk between the reproductive and thyroid systems. (See Sex Dev. 2009;3(6):333-41)
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The candidate will have a strong interest in receptors. You will isolate and characterize receptors for novel neuropeptides important for reproduction. We are trying to define a new hormone system based on the granin-derived peptide secretoneurin (see Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1290-7). Are you up for the challenge?
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My lab has uncovered novel candidate genes and proteins regulated by the neurotransmitter dopamine that we believe are important for hypothalamic function and remodeling. This was possible because we developed methods for global transcriptomic and quantitative proteomic analyses [25,49]. We want to further understand the relationship between mRNA and protein in the brain at the large scale (see PLoS One. 2010 Aug 20;5(8):e12338).
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The University of Ottawa has announced a new scholarship program. If you have the equivalent of A minus (A-) your tuition may be covered for the duration of your tenure here. Check this out at http://www.grad.uottawa.ca/Default.aspx?tabid=1472
See the following website for background information on our lab: http://www.teamendo.ca.
Please send your CV, list of courses with marks and the names of at least 2 references to Dr. Vance Trudeau at trudeauv@uottawa.ca. The positions will remain open until suitable individuals are identified. Posted as of Apr. 19, 2011.
Last updated: Dec. 21, 2009